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Ali Mahdavi

PhD Student

Ali Mahdavi

Bernstein Center Freiburg
Hansastraße 9a
79104 Freiburg
Germany
Fon: +33 (0) 767 754 12

https://www.u1114.inserm.fr/en/ h
https://www.bcf.uni-freiburg.de/

 

Research Project

  • Neurophysiological and theoretical study of cellular and synaptic mechanisms underlying aberrant thalamocortical oscillations in a rodent model of psychotic transition.

 

Research Topics

  • The underlying mechanisms of the sleep disturbances in schizophrenia and patients with psychotic disorders
  • Psychosis transition
  • Somatosensory CT-TRN-TC loop circuit
  • Computational and experimental model of NREM sleep
  • Sleep spindles
  • NMDA glutamate receptors
  • Ketamine
  • Thalamus
  • Neural oscillations

 

Techniques

  • Computational neuroscience
  • Experimental Neuroscience
  • Simulation of spiking neural networks
  • Conductance-based neuron models
  • In vivo electrophysiological multisite cell-to-network recordings
  • Data analysis and signal processing
  • EEG and LFP
  • Python
  • NEST
  • ScienceWorks, DataWave
  • pCLAMP 10

 

Academic Background

  • Since 2016, PhD student at the BCF (Freiburg, Germany) and INSERM U1114 (Strasbourg, France)
  • 2010 - 2013: M.Sc. in Biomedical Engineering, title of the thesis: Neurophysiological analysis of schizophrenia based on dysfunction of the glutamatergic system and abnormal synaptic transmission using a tripartite synapse model, at the University of Tehran, Iran
  • 2013 - 2015: Two-year teaching and research assistant in the Human Motion Control and Computational Neuroscience Lab of Dr. Fariba Bahrami, University of Tehran, Iran
  • 2005 - 2010: B.Sc. in Electronic Engineering, at the Guilan University, Guilan, Iran

 

Journal Publications

  • Mahdavi A, Qin Y, Aubry A.-S, Cornec D, Kulikova K, Pinault D, “A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat”, Schizophrenia Research, Volume 222, 2020, Pages 362-374, ISSN 0920-9964, https://doi.org/10.1016/j.schres.2020.04.029

 

Conference Papers

  • Mahdavi A, Bahrami A, Janahmadi M, “Neurophysiological analysis of schizophrenia based on dysfunction of the glutamatergic system using a tripartite synapse model,” 20th Iranian Conference on Biomedical Engineering (ICBME), pp. 183–188, 2013.
  • Mahdavi A, Bahrami F, Janahmadi M, “Studying the effect of dysregulation of NMDA receptors function in schizophrenia,” 22nd Iranian Conference on Electrical Engineering (ICEE), pp. 1990–1995, 2014.
  • Mahdavi A, Mirjalili M, Bahrami F, Janahmadi M, “Hypofunction of NMDA receptors due to the hyperactivation of dopamine receptors in the hippocampal synapses of schizophrenia based on a mathematical model,” 22th Iranian Conference on Biomedical Engineering (ICBME), 2015.
  • Mahdavi A, Bahrami F, and Janahmadi M, "Analysis of impaired LTP in schizophrenia using an extended mathematical model of a tripartite synapse," 2015 22nd Iranian Conference on Biomedical Engineering (ICBME), Tehran, 2015, pp. 76-80.
  • Borjkhani M, Mahdavi A, Bahrami F, “A mathematical model for neuron astrocytes interactions in hippocampus during addiction,” 21th Iranian Conference on Biomedical Engineering (ICBME), pp. 303–308, 2014. - Andani M.E., Mahdavi A., Bahrami F and Fiorio M, "Placebo-induced changes in behavioural parameters during gait: a pilot study," 2015 22nd Iranian Conference on Biomedical Engineering (ICBME), Tehran, 2015, pp. 337-340. 
  • Mohammadi M, Mahdavi A, Farashahi S-G, Bahrami F, “Allocentric spatial navigation impairment in schizophrenic subject: A model-based study,” 23rd Iranian Conference on Electrical Engineering (ICEE), 2015, pp. 125–130, 2015.