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Clay Reid (Harvard Medical School, Department of Neurobiology, Boston, MA, USA)

"Structural and functional imaging of a cortical circuit" / Monday, March 28, 2011, 17:15 h
When Mar 28, 2011
from 04:00 PM to 05:30 PM
Where Lecture Hall, Biology I, Hauptstr. 1, Freiburg
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The Bernstein Center Freiburg

Bernstein Seminar
Clay Reid
Harvard Medical School
Department of Neurobiology
Boston, MA, USA

Structural and functional imaging
of a cortical circuit

Monday, March 28, 2011

16:00 h (sharp)

Lecture Hall
Biology I
Hauptstr. 1
79104 Freiburg
In the cerebral cortex, local circuits consist of tens of thousands of neurons, each of which makes thousands of synaptic connections. Perhaps the biggest impediment to understanding these networks is that we have no wiring diagrams of their interconnections. Even if we had a partial or complete wiring diagram, however, understanding the network would also require information about each neuron’s function. Here we show that the relationship between structure and function can be studied in the cortex with a combination of in vivo physiology and network anatomy. We used two-photon calcium imaging to characterize a functional property — the preferred stimulus orientation — of a group of neurons in the mouse primary visual cortex. Large-scale electron microscopy of serial thin sections was then used to trace a portion of these neurons’ local network. Consistent with a prediction from recent physiological experiments, inhibitory interneurons received convergent anatomical input from nearby excitatory neurons with a broad range of preferred orientations, although weak biases could not be rejected.
The talk is open to the public. Guests are cordially invited!


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