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Christoph Kirst (Max Planck Institute for Dynamics and Self-Organization, Network Dynamics Group, Göttingen, Germany)

"Dynamic Neuronal Excitability" / Tuesday, November 13, 2012, 17:15 h
When Nov 13, 2012
from 05:15 PM to 06:45 PM
Where Lecture Hall, Hansastr. 9a
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The Bernstein Center Freiburg

Bernstein Seminar
Christoph Kirst
Max Planck Institute for Dynamics and Self-Organization
Network Dynamics Group
Göttingen, Germany

Dynamic Neuronal Excitability

Tuesday, November 13, 2012

17:15 h

Lecture Hall (ground floor)
Bernstein Center Freiburg
Hansastraße 9A
79104 Freiburg


Neurons generally show two types of excitability [1,2]: Type I neurons support arbitrary long inter-spike-intervals, while type II neurons start firing with a non-zero frequency upon current injection.


Here we show that a transition from type I to type II can be dynamically induced in a large number of conductance-based neuron models (including Wang-Buszaki, Morris-Lecar, Connor- Stevens, Erisir et al.), e.g. by an increase in leak conductance. We mathematically prove that the bifurcation structure of this transition is organized by a degenerate Bogdanov-Takens-cusp bifurcation point of co-dimension 3 [3] which implies a switch from type I to type II for the spiking dynamics, a transition from integration to resonance near spike threshold, as well as a region of bistability of resting and regular spiking dynamics.

We confirm these predictions experimentally for different neurons using dynamic patch clamp recordings. We further find that activation of synaptic shunting inhibition is sufficient to induce the excitability switch and discuss consequences for the collective neuronal network dynamics.

[1] A. L. Hodgkin, J. Physiol. 107, 165 (1948).
[2] E. M. Izhikevic, Dynamical Systems in Neuroscience, MIT Press (2007).
[3] F. Dumortier, R. Roussarie, J. Sotomayor, and H. Zoladek.
Bifurcations of Planar Vector Fields, Springer (1991).


The talk is open to the public. Guests are cordially invited!



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