You are here: Home Bernstein Seminar 2017 Philipp Schnepel, Max Delbrück …

Banner Bernstein Seminar

Philipp Schnepel, Max Delbrück Center for Molecular Medicine, Berlin | Hyperexcitability in Mouse Models of Autism-Spectrum Disorders

Bernstein Seminar
When May 23, 2017
from 05:15 PM to 06:45 PM
Where BCF Lecture Hall, Hansastr. 9a
Contact Name
Add event to calendar vCal
iCal

 

Abstract

Autism Spectrum Disorder (ASD) is a genetically heterogeneous disorder for which the causal mechanism remains unidentified. It is hypothesized that a common pathology exists that is defined by an increased excitation-inhibition (E-I) ratio and hyperexcitability at the neural circuit level. Reports on deficits in interneuron number and of increased E-I ratio collectively suggest circuit excitability in ASD1-7 . To test this model, we are comparing local circuit physiology and sensory processing in primary somatosensory (S1) cortex across multiple ASD model mouse strains. S1 is a reasonable site to investigate ASD circuit dysfunction since 80-90% of ASD patients show sensory abnormalities including tactile hypersensitivity 8 . Here, we report initial results from three ASD strains: contactin associated protein-like 2 (Cntnap2), fragile X mental retardation 1 (Fmr1) and microdeletion on chromosome 16 (16p11.2) mice. Although whole-cell recordings in L2/3 of S1 slices indicate an increase in E-I-ratio, in vivo extracellular recordings show heterogeneous results across the different strains, suggesting that the hyperexcitability hypothesis needs to be revisited as a general mechanism for autism-spectrum disorders.

Literature

  • Levy et al., Lancet 374, 1627 (2009).
  • Markram and Markram, Front Hum Neurosci 4,224 (2010)
  • Peñagarikano et al., Cell 147, 235 (2011).
  • Bureau et al., Journal of Neuroscience, 28, 5178 (2008).
  • Gogolla, et al. J Neurodev Disord1, 172 (2009).
  • Rubenstein and Merzenich, Genes Brain Behav. 2, 255(2003).
  • Yizhar et al. Nature 477, 171 (2011).
  • Geschwind, Annual Review of Medicine 60, 367 (2009).

 

More information about this event…

 

Supported by

Bernstein Center Freiburg | PhD Program BrainDiscDeutscher Akademischer Austauschdienst DAADFederal Ministery of Education and ResearchCarl Zeiss FoundationNeurexNeuroCampusEU Development FundEU InterregNeurAGBrainLinks BrainTools

 

All upcoming scientific events

Back to overview

All Bernstein Seminars

2024 |  202320222021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

Filed under: