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Sonja Grün, Inst. of Neuroscience and Medicine & Inst. of Advanced Simulation, Research Center Jülich & Theoretical Systems Neurobiology, RWTH Aachen | Fine temporal spike coordination in relation to behavior

Bernstein Seminar
When Feb 05, 2019
from 05:15 PM to 06:00 PM
Where Lecture Hall, Bernstein Center Freiburg
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Hosted by Ad Aertsen

The computational role of spike coordination at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological technology to record from hundred(s) of neurons simultaneously provide the opportunity to observe coordinated spiking activity of larger number of neurons. We developed a method that combines data mining and statistical evaluation to search for significant synchronous spike patterns in massively parallel spike trains (Torre et al., 2013). The method solves the computational and multiple testing problems raised by the high dimensionality of the data.

Application of this method on simultaneous recordings of macaque monkey motor cortex engaged in an instructed-delay reachto-grasp task revealed specific patterns in relation to motor behavior (Torre et al, 2016). We were able to extend this method also to the detection and significance evaluation of spatio-temporal spike patterns, i.e. with temporal delay between the spikes (Yegenoglu et al, 2016; Quaglio et al, 2017; Quaglio, 2018). The spatio-temporal patterns we find are surprising: they involve only a relatively small number of neurons, whereas neurons are multiply part in different patterns. I will discuss possible implications and interpretations of the findings.

Sonja Grün, Inst. of Neuroscience and Medicine & Inst. of Advanced Simulation | Research Center Jülich
& Theoretical Systems Neurobiology | RWTH Aachen


Supported by

Bernstein Center Freiburg | PhD Program BrainDiscDeutscher Akademischer Austauschdienst DAADFederal Ministery of Education and ResearchCarl Zeiss FoundationNeurexNeuroCampusEU Development FundEU Interreg


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