You are here: Home Bernstein Seminar 2024 Aadhar Sharma: The Dynamics of …

Banner Bernstein Seminar

Aadhar Sharma: The Dynamics of Adult Neurogenesis in the Dentate Gyrus

[Special Bernstein Seminar] with the Bernstein-CorTec Awardee 2023
When Feb 28, 2024
from 12:15 PM to 01:00 PM
Where Bernstein Center, Hansastr. 9a, Lecture Hall.
Contact Name
Add event to calendar vCal
iCal

 

The seminar features a presentation of Aadhar Sharma about his awarded master thesis. In the video below he gives a little sneak peek.

 

Video

 

Abstract

 The large-scale structural organization of the adult brain is relatively stable and unchanging. However, in some animal species, including humans, new neurons are born and integrated into the hippocampal network throughout lifetime. The hippocampus is involved in functions such as memory formation, contextual pattern separation, and spatial navigation, among others. However, it is currently not clear how the integration of newborn neurons in the hippocampus affects its function.

 Most neurons in the hippocampus are born early in development and have functional properties that are distinct from adult-born cells. These initially distinct properties of adult-born cells gradually converge to those of developmentally-born neurons in an age-dependent manner. It is suspected that this functional distinction and gradual maturation is responsible for the integration of adult-born cells into the existing brain networks.

 To assay the dynamics of adult neurogenesis, we developed a model in which adult-born neurons form plastic connections and interact with other neurons in the hippocampal network. Large-scale numerical simulations revealed that age-dependent functional properties are indeed critical for the integration of adult-born neurons into the preexisting network. Furthermore, an analysis of the network dynamics suggests that, if large numbers of adult-born neurons are rapidly added, pathological states may emerge. Data also suggest that adult-born and developmentally-born neurons may be involved in a competition-based appropriation of synapses.

About the speaker and his research

Hosted by Ad Aertsen

 

 

All upcoming scientific events

Back to overview

All Bernstein Seminars

2024 |  202320222021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

Filed under: