Special Bernstein Seminar with the Bernstein-CorTec Awardees Enya Paschen and Eric Klein: Save the Date
| When |
Jan 14, 2025
from 05:15 PM to 06:15 PM |
|---|---|
| Where | Bernstein Center, Hansastr. 9a, Lecture Hall. |
| Contact Name | Gundel Jaeger |
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Short Video Introduction about the Awardees 2024
Please note: Enya's talk will be transmitted via Zoom.
Enya Paschen: Physiological and Behavioral Implications of Neuromodulation in Experimental Epilepsy
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy in adults. Despite advances in pharmacological, surgical and neuromodulatory treatment strategies, many patients do not achieve adequate control of their epileptic seizures. Enya Paschen's dissertation focussed on the development of new neuromodulation techniques and their effects on seizure activity and cognitive functions in MTLE. She found that low-frequency stimulation (LFS, optogeneric or electrical) in the hippocampus suppresses seizure onset and does not impair core hippocampal functions such as learning, spatial navigation and memory. She was thus able to present LFS as an effective stimulation protocol and an alternative therapeutic approach for treatment-resistant MTLE patients.
Eric Klein: Flexible μLED-Based Optical Cochlear Implant for High-Resolution Stimulation
His thesis describes the first functional optical cochlear implant (oCI) based on integrated μLEDs, successfully applied in vivo. To integrate the highest possible number of individually addressable μLEDs, he evaluated different routing schemes and implemented both single- and multi-layer metallization. Additionally, various measures were taken to optimize light extraction, direction, and reflection. These optimizations ultimately enabled, in collaboration with project partners from Göttingen, the demonstration that a single μLED can efficiently stimulate optogenetically modified nerve cells in the cochlea. It was also shown that the μLED arrays of the oCIs reduce spectral spread - compared to a clinical-style electrical cochlear implant - by up to 5 octaves, thereby providing significantly higher frequency resolution for cochlear implant patients.