Bursts with high and low load of epileptiform spikes show context-dependent correlations in epileptic mice
Figure Legend see below. Click to view full-size image.
Such low-load events indeed had dual nature: If they were more frequent, the pauses between phases with severe events tended to be longer; however, their frequency also increased before severe activity. Additional research will be necessary to discriminate between these two situations and to identify the processes that create them. It is further unclear if these observations in mice can be compared to epileptic activity in humans.
Figure Legend
Low-load bursts might at times prevent the mouse from being dragged into more severe epileptic activity.
DOI:10.1523/ENEURO.0299-18.2019
Contact
Katharina Heining
Tel.: +49 (0)761 203 67744
E-mail: katharina.heining@bcf.uni-freiburg.de
Prof. Dr. Ulrich Egert
Tel.: +49 (0)761 203-7524
E-mail: egert@imtek.uni-freiburg.de
University of Freiburg
Bernstein Center Freiburg
Hansastr. 9a
79104 Freiburg
and
Faculty of Engineering
Biomicrotechnology, Dept. of Microsystems Engineering
Georges-Köhler-Allee 102
79110 Freiburg